Fluorescence diagnostics of head and neck cancer utilizing oral administration of delta-amino levulinic acid

Katarina Svanberg M.D.; Ingrid Wang-Nordman; R. Rydell; A. Elner; J. Wennerberg; Laudelina C. Pais Clemente; E. Cardosa; R. Pratas; Manuel P. Pais Clemente; Stefan Andersson-Engels; Sune Svanberg

doi:10.1117/12.203438

1 March 1995 Fluorescence diagnostics of head and neck cancer utilizing oral administration of delta-amino levulinic acid

Katarina Svanberg M.D., Ingrid Wang-Nordman, R. Rydell, A. Elner, J. Wennerberg, Laudelina C. Pais Clemente, E. Cardosa, R. Pratas, Manuel P. Pais Clemente, Stefan Andersson-Engels, Sune Svanberg

Author Affiliations +

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203438
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Tissue fluorescence measurements utilizing a point monitoring fluorosensor and a multi-color fluorescence imaging system were performed in patients with various malignant tumors in the head and neck region. Also precancerous lesions were investigated and characterized by means of laser-induced fluorescence. Oral administration of low-dose (delta) -amino levulinic acid was used for the induction of protoporphyrin IX, which exhibits a strong fluorescence in the red wavelength region. The blue-green fluorescence emitted from the tissue natural chromophores was also utilized for tumor demarcation. By incorporating both Protoporphyrin IX and natural fluorescence in a tumor demarcation criterion a tumor demarcation with a tumor-to-normal-surrounding-tissue of about 5 - 10:1 contrast was achieved. Hypertrophic tissue did not exhibit tumor specific signals.

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Katarina Svanberg M.D., Ingrid Wang-Nordman, R. Rydell, A. Elner, J. Wennerberg, Laudelina C. Pais Clemente, E. Cardosa, R. Pratas, Manuel P. Pais Clemente, Stefan Andersson-Engels, and Sune Svanberg "Fluorescence diagnostics of head and neck cancer utilizing oral administration of delta-amino levulinic acid", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203438

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