Small-area fiber-coupled scintillation camera for imaging beta-ray distributions intraoperatively

Lawrence R. MacDonald; Martin P. Tornai; Craig S. Levin; J. Park; Muzaffer Atac; David B. Cline; Eric G. Hoffman

doi:10.1117/12.218645

8 September 1995 Small-area fiber-coupled scintillation camera for imaging beta-ray distributions intraoperatively

Lawrence R. MacDonald, Martin P. Tornai, Craig S. Levin, J. Park, Muzaffer Atac, David B. Cline, Eric G. Hoffman

Proceedings Volume 2551, Photoelectronic Detectors, Cameras, and Systems; (1995) https://doi.org/10.1117/12.218645
Event: SPIE's 1995 International Symposium on Optical Science, Engineering, and Instrumentation, 1995, San Diego, CA, United States

Abstract

A small area, imaging, scintillation probe is being developed for locating small amounts of radio-labeled malignant tissue during surgery. Preliminary in brain surgery, avoiding the removal of excess tissue is a priority. It is possible to locate the main body of a brain tumor both before and during surgery, but once the bulk of the tumor is excised the identification of residual malignant tissue is difficult. A probe that covers an area of 1-2 cm² with an intrinsic resolution of 1-2 mm could locate small tumor masses that pose a threat of recurrence of the disease, and prevent removal of healthy tissue. A pre-operative injection of tumor seeking, beta emitting radiopharmaceutical (e.g. ¹⁸fluorodeoxyuridine-FDUR-) will label the tumor. The limited range of beta-rays ensures proximity upon successful detection. Plastic scintillators are used for beta detection, and visible light photon counters (VLPCs) detect the scintillation light. For maneuverability in and around the surgical cavity, the scintillators are coupled to the VLPCs via 2 m of optical fiber. An imaging device can cover the tissue bed in a time compatible with surgery, as opposed to a single element detector on the order of 1-2 mm in size with comparable resolution. An imager also distinguishes high background rates (such as from annihilation gammas in FDUR) and concentrations of activity.

Citation Download Citation

Lawrence R. MacDonald, Martin P. Tornai, Craig S. Levin, J. Park, Muzaffer Atac, David B. Cline, and Eric G. Hoffman "Small-area fiber-coupled scintillation camera for imaging beta-ray distributions intraoperatively", Proc. SPIE 2551, Photoelectronic Detectors, Cameras, and Systems, (8 September 1995); https://doi.org/10.1117/12.218645

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