Frequency domain optical tomography in human tissue

Yuqi Yao; Yao Wang; Yaling Pei; Wenwu Zhu; Jenhun Hu; Randall Locke Barbour

doi:10.1117/12.224168

9 October 1995 Frequency domain optical tomography in human tissue

Yuqi Yao, Yao Wang, Yaling Pei, Wenwu Zhu, Jenhun Hu, Randall Locke Barbour

Proceedings Volume 2570, Experimental and Numerical Methods for Solving Ill-Posed Inverse Problems: Medical and Nonmedical Applications; (1995) https://doi.org/10.1117/12.224168
Event: SPIE's 1995 International Symposium on Optical Science, Engineering, and Instrumentation, 1995, San Diego, CA, United States

Abstract

In this paper, a reconstruction algorithm for frequency-domain optical tomography in human tissue is presented. A fast and efficient multigrid finite difference (MGFD) method is adopted as a forward solver to obtain the simulated detector responses and the required imaging operator. The solutions obtained form MGFD method for 3D problems with weakly discontinuous cocoefficients are compared with analyzed solutions to determine the accuracy of the numerical method. Simultaneous reconstruction of both absorption and scattering coefficients for tissue-like media is accomplished by solving a perturbation equation using the Born approximation. This solution is obtained by a conjugate gradient descent method with Tikhonov regularization. Two examples are given to show the quality of the reconstruction results. Both involve the examination of anatomically accurate optical models of tissue derived from segmented 3D magnetic resonance images to which have been assigned optical coefficients to the designated tissue types. One is a map of a female breast containing two small 'added pathologies', such as tumors. The other is a map of the brain containing a 'local bleeding' area, representing a hemorrhage. The reconstruction results show that the algorithm is computationally practical and can yield qualitatively correct geometry of the objects embedded in the simulated human tissue. Acceptable results are obtaiend even when 10% noise is present in the data.

Citation Download Citation

Yuqi Yao, Yao Wang, Yaling Pei, Wenwu Zhu, Jenhun Hu, and Randall Locke Barbour "Frequency domain optical tomography in human tissue", Proc. SPIE 2570, Experimental and Numerical Methods for Solving Ill-Posed Inverse Problems: Medical and Nonmedical Applications, (9 October 1995); https://doi.org/10.1117/12.224168

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available