Laser-tissue interaction during transmyocardial laser revascularization

E. Duco Jansen; Martin Frenz; Kamuran A. Kadipasaoglu; T. Joshua Pfefer; Hans Joerg Altermatt; Massoud Motamedi; Ashley J. Welch

doi:10.1117/12.239990

17 May 1996 Laser-tissue interaction during transmyocardial laser revascularization

E. Duco Jansen, Martin Frenz, Kamuran A. Kadipasaoglu, T. Joshua Pfefer, Hans Joerg Altermatt, Massoud Motamedi, Ashley J. Welch

Author Affiliations +

Proceedings Volume 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI; (1996) https://doi.org/10.1117/12.239990
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

The clinical procedure known as transmyocardial revascularization has recently seen its renaissance. Despite the promising preliminary clinical results, the associated mechanisms are subject to much discussion. This study is an attempt to unravel the basics of the interaction between 800 W carbon-dioxide laser radiation and biological tissue. Time-resolved flash photography was used to visualize the laser-induced channel formation in water and tissue phantoms. In addition laser-induced pressures were measured. Channel depth was shown to increase logarithmically with time (i.e. with pulse duration) in water, tissue phantoms and porcine myocardium. Pressure measurements show numerous small transients during the laser pulse which corresponded to the local and partial collapse of the formed channel already during the pulse. It was shown that in tissue, 20 mm of myocardium is perforated in 25 ms. Increasing the pulse duration only has a small effect on the maximum transversible thickness while histology shows that thermal damage around the crater increased with increasing pulse duration.

Citation Download Citation

E. Duco Jansen, Martin Frenz, Kamuran A. Kadipasaoglu, T. Joshua Pfefer, Hans Joerg Altermatt, Massoud Motamedi, and Ashley J. Welch "Laser-tissue interaction during transmyocardial laser revascularization", Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); https://doi.org/10.1117/12.239990

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