Dynamics of intramyocardial blood volume in the intact animal: evaluation with SPECT

Thomas Behrenbeck; Michael K. O'Connor; David A. Foley; Erik Leo Ritman M.D.

doi:10.1117/12.237876

8 April 1996 Dynamics of intramyocardial blood volume in the intact animal: evaluation with SPECT

Thomas Behrenbeck, Michael K. O'Connor, David A. Foley, Erik Leo Ritman M.D.

Proceedings Volume 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images; (1996) https://doi.org/10.1117/12.237876
Event: Medical Imaging 1996, 1996, Newport Beach, CA, United States

Abstract

Variations in blood volume in the myocardium through the cardiac cycle have previously been considered constant. More recent studies have indicated a considerably variation from end diastole to end systole. These studies were nearly all performed under non-physiological conditions using muscle preparations or ex situ cardiac preparations. This study was designed to assess the dynamic changes of the intramyocardial blood volume in the intact animal under normal flow conditions using single photon emission computed tomography (SPECT). Radiolabeled, 15 micrometers diameter, microspheres were emoblized in the myocardial microcirculation of dogs with subsequent scans in a TRIAD single-photon-emission-computed- tomography scanner. Gated images were obtained at 63 msec intervals encompassing the entire heart. Transmural voxel (equals volume element) brightness was measured in all tomographic images reflecting global and regional count density in the myocardium. There was a significant decrease in the blood volume from end diastole to end systole (10.8 cc/100 mL muscle volume; p < 0.00001). The decrease from diastole (ED) to systole (ES) in image brightness at the apex, mid ventricle, and base were: -5.7% (p < 0.01, apex vs. base), -4.7% (p < 0.01, mid ventricle vs. base) and +2.2%, respectively. Conclusions: (1) respiratory and ECG gated SPECT images allow measurement of intramyocardial blood volume changes throughout the cardiac cycle in the intact animal; (2) myocardial blood content is maximum at ED; (3) these findings progressively diminished in magnitude from apex to base.

Citation Download Citation

Thomas Behrenbeck, Michael K. O'Connor, David A. Foley, and Erik Leo Ritman M.D. "Dynamics of intramyocardial blood volume in the intact animal: evaluation with SPECT", Proc. SPIE 2709, Medical Imaging 1996: Physiology and Function from Multidimensional Images, (8 April 1996); https://doi.org/10.1117/12.237876

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