Fluorescence photodetection of urothelial neoplastic foci in superficial bladder cancer

Patrice Jichlinski; Martin Forrer; Jerome C. Mizeret; Daniel Braichotte; Georges A. Wagnieres; Georges Zimmer; Louis Guillou; Franz R. Schmidlin M.D.; Peter Graber M.D.; Hubert van den Bergh; Hans-Juerg Leisinger M.D.

doi:10.1117/12.275078

22 May 1997 Fluorescence photodetection of urothelial neoplastic foci in superficial bladder cancer

Patrice Jichlinski, Martin Forrer, Jerome C. Mizeret, Daniel Braichotte, Georges A. Wagnieres, Georges Zimmer, Louis Guillou, Franz R. Schmidlin M.D., Peter Graber M.D., Hubert van den Bergh, Hans-Juerg Leisinger M.D.

Author Affiliations +

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275078
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to the bladder tumor multiplicity and the presence of concomitant 'plane' tumors such as high grade dysplasia and carcinoma in situ (CIS). This study on 33 patients tries to demonstrate the interest of fluorescence cystoscopy in transurethral resection of superficial bladder cancer The method is based on the detection of the protoporphyrin IX (PpIX) induced fluorescence in urothelial cancer cells by topical administration of 5- aminolevulinic acid (ALA). The sensitivity and the specificity of this procedure on apparently normal mucosa in superficial bladder cancer is respectively estimated at 82.9% and 81.3%. Thus, fluorescence cystoscopy is a simple and reliable method in mapping the bladder mucosa, especially in case of multifocal bladder disease and it facilitates the screening of occult dysplasia.

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Patrice Jichlinski, Martin Forrer, Jerome C. Mizeret, Daniel Braichotte, Georges A. Wagnieres, Georges Zimmer, Louis Guillou, Franz R. Schmidlin M.D., Peter Graber M.D., Hubert van den Bergh, and Hans-Juerg Leisinger M.D. "Fluorescence photodetection of urothelial neoplastic foci in superficial bladder cancer", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275078

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