Enhanced optical scattering by microbubbles

Quing Zhu; Britton Chance; W. Timothy Jenkins; Yutao Zhang

doi:10.1117/12.280242

18 August 1997 Enhanced optical scattering by microbubbles

Quing Zhu, Britton Chance, W. Timothy Jenkins, Yutao Zhang

Proceedings Volume 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II; (1997) https://doi.org/10.1117/12.280242
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Optical properties of microbubbles (EchoGen, Sonus Pharmaceuticals, WA) have been evaluated using a 200 MHz phase modulation system. Studies have shown that the mean optical pathlength has been increased at 754 nm by an average of 1.5 mm (std. 0.46 mm) when EchoGen was administered to 11 Fischer rats at the dose of 100 (mu) l or 150 (mu) l. As a comparison, the mean pathlength has been decreased at the same wavelength by an average of 4.2 mm (std. 3.66 mm) when indocyanine green (ICG) was administered at the dose of 100 (mu) l. The mean pathlength change at 816 nm is very small and the possible reasons are discussed. Potential applications of using microbubbles to provide a co-registration of ultrasound and light images of growing tumors are discussed.

Citation Download Citation

Quing Zhu, Britton Chance, W. Timothy Jenkins, and Yutao Zhang "Enhanced optical scattering by microbubbles", Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); https://doi.org/10.1117/12.280242

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