Bio-speckle method for retinal blood flow analysis: flexible correlation measurements

Yoshihisa Aizu; Toshimitsu Asakura; Atsushi Kojima

doi:10.1117/12.273603

2 May 1997 Biospeckle method for retinal blood flow analysis: flexible correlation measurements

Yoshihisa Aizu, Toshimitsu Asakura, Atsushi Kojima

Proceedings Volume 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology; (1997) https://doi.org/10.1117/12.273603
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Bio-speckle flowmetry is useful for measuring the blood flow velocity in human retinal vessels, but it often suffers rom eye-movement artifacts and other external moving factors. To solve this problem, we studied in this paper here a flexible correlation-analyzing system which is able to extract effectively the blood flow information from erroneous data influenced by a displacement of the measuring point. On the basis of the photon correlation technique, the system directly stores the sequential counts of photo-electron pulses into the memory. After a measurement, the stored data are read out and used to calculate the first-order statistics of time-integrated speckle fluctuations and the autocorrelation function with an arbitrary delay-time unit for an arbitrary period. These results are used to specify the displacement of the measuring point due to eye movements and to eliminate erroneous data. The usefulness of this technique was verified for a glass capillary model and human retinal vessels.

Citation Download Citation

Yoshihisa Aizu, Toshimitsu Asakura, and Atsushi Kojima "Biospeckle method for retinal blood flow analysis: flexible correlation measurements", Proc. SPIE 2982, Optical Diagnostics of Biological Fluids and Advanced Techniques in Analytical Cytology, (2 May 1997); https://doi.org/10.1117/12.273603

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available