Gd-meso-tetraphenylporphyrins: synthesis, encapsulation into liposomes, and characterization of the resulting preparations

Dmitry B. Berezin; Raymond Bonnett; Maria Africa de Madariaga; Sergio I. Molina; Margarita Mora; Maria Lluisa Sagrista; Maria Asuncion Valles

doi:10.1117/12.297829

29 December 1997 Gd-meso-tetraphenylporphyrins: synthesis, encapsulation into liposomes, and characterization of the resulting preparations

Dmitry B. Berezin, Raymond Bonnett, Maria Africa de Madariaga, Sergio I. Molina, Margarita Mora, Maria Lluisa Sagrista, Maria Asuncion Valles

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297829
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

POPC, DPPC/DMPC and POPC/OOPS liposomes containing gadolinium(III) meso-tetraphenylporphyrin and gadolinium(III) meso-tetra(4-pyridyl)porphyrin have been prepared by different techniques, their porphyrin and lipid contents have been evaluated, and the size and stability of the liposomes have been determined. The results show the influence of the method of preparation on the amount of Gd-porphyrin incorporated, and that of the lipid composition on the incorporation efficiency and stability of the Gd(III) porphyrin trapped in the liposomes, as well as the presence of strong lipid to porphyrin association at least in the case of the DPPC/DMPC liposomes.

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Dmitry B. Berezin, Raymond Bonnett, Maria Africa de Madariaga, Sergio I. Molina, Margarita Mora, Maria Lluisa Sagrista, and Maria Asuncion Valles "Gd-meso-tetraphenylporphyrins: synthesis, encapsulation into liposomes, and characterization of the resulting preparations", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297829

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