Phosphosubstituted phthalocyanine derivatives as effective photosensitizers for PDT

Gennadii A. Meerovich; Eugeny A. Lukyanets; Olga A. Yuzhakova; Nadezgda L. Torshina; Victor B. Loschenov; Alexander A. Stratonnikov; Eugenia A. Kogan; Georgy N. Vorozhtsov; Andrei V. Kunetz; Yury P. Kuvshinov; Boris K. Poddubny; Anna I. Volkova; Anna M. Posypanova

doi:10.1117/12.297804

29 December 1997 Phosphosubstituted phthalocyanine derivatives as effective photosensitizers for PDT

Gennadii A. Meerovich, Eugeny A. Lukyanets, Olga A. Yuzhakova, Nadezgda L. Torshina, Victor B. Loschenov, Alexander A. Stratonnikov, Eugenia A. Kogan, Georgy N. Vorozhtsov, Andrei V. Kunetz, Yury P. Kuvshinov, Boris K. Poddubny, Anna I. Volkova, Anna M. Posypanova

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297804
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The photodynamic therapy in the spectral range 690 - 750 nm is more perspective for treatment of the deeply located tumors because the absorption of tissue has a significant minimis in this spectral range. A series of phosphosubstituted phthalocyanine derivatives were studied in vitro and in experiment on white mice. It has been shown that photodynamic therapy using these photosensitizers was very effective and induced the prominent tumor damage (necrosis, apoptosis), inhibition of its growth and stimulation of antitumor desmoplastic reaction.

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Gennadii A. Meerovich, Eugeny A. Lukyanets, Olga A. Yuzhakova, Nadezgda L. Torshina, Victor B. Loschenov, Alexander A. Stratonnikov, Eugenia A. Kogan, Georgy N. Vorozhtsov, Andrei V. Kunetz, Yury P. Kuvshinov, Boris K. Poddubny, Anna I. Volkova, and Anna M. Posypanova "Phosphosubstituted phthalocyanine derivatives as effective photosensitizers for PDT", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297804

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