Heat-induced changes of the optical properties of liver tissue

Joerg-Peter Ritz; Andre Roggan; Christoph Martin Isbert; Dirk Albrecht; Christoph-Thomas Germer; Gerhard J. Mueller; Heinz-Johannes Buhr

doi:10.1117/12.300823

19 January 1998 Heat-induced changes of the optical properties of liver tissue

Joerg-Peter Ritz, Andre Roggan, Christoph Martin Isbert, Dirk Albrecht, Christoph-Thomas Germer, Gerhard J. Mueller, Heinz-Johannes Buhr

Author Affiliations +

Proceedings Volume 3193, Photothermal Therapies in Medicine; (1998) https://doi.org/10.1117/12.300823
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

For prediction of the effectiveness of laser-induced thermotherapy of liver metastases and for the understanding and optimal use of laser applications in medicine, especially for dosimetrical questions, the knowledge of the specific optical properties and their thermo-induced changes is important. In our study we were able to evaluate the optical properties of human liver tissue and metastatic tissue. Furthermore, we investigated the dynamic temperature behavior between 45 degree(s)C and 80 degree(s)C at three different exposure times using a double-integrating sphere system. We found significant differences between normal and metastatic tissue resulting in a higher optical penetration depth in the tumorous tissue. During the coagulation the absorption coefficient, anisotropy and optical penetration depth decreased significantly in the temperature range from 45 degree(s)C to 65 degree(s)C, whereas the scattering coefficient increased. Above and below this temperature range the changes of the optical properties were not significant. The coagulation rate differed between the exposure times.

Citation Download Citation

Joerg-Peter Ritz, Andre Roggan, Christoph Martin Isbert, Dirk Albrecht, Christoph-Thomas Germer, Gerhard J. Mueller, and Heinz-Johannes Buhr "Heat-induced changes of the optical properties of liver tissue", Proc. SPIE 3193, Photothermal Therapies in Medicine, (19 January 1998); https://doi.org/10.1117/12.300823

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