Influence of light irradiation on blood oxygen saturation level in vitro and in vivo during photodynamic therapy

Alexander A. Stratonnikov; Alexandre Yu. Douplik; D. V. Klimov; Victor B. Loschenov; S. V. Mizin

doi:10.1117/12.308140

19 May 1998 Influence of light irradiation on blood oxygen saturation level in vitro and in vivo during photodynamic therapy

Alexander A. Stratonnikov, Alexandre Yu. Douplik, D. V. Klimov, Victor B. Loschenov, S. V. Mizin

Author Affiliations +

Proceedings Volume 3247, Optical Methods for Tumor Treatment and Detections: Mechanisms and Techniques in Photodynamic Therapy VII; (1998) https://doi.org/10.1117/12.308140
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) is an effective method to treat cancer and other nononcological lesions by means of light action on photosensitizer in tissue. It is assumed that the destroying effect is mainly due to the formation of singlet oxygen resulting from the interaction of light excited photosensitizer with molecular oxygen (triplet ground state). So the destroying effect will be proportional to the rate of singlet oxygen formation which in turn depends on light intensity, photosensitizer concentration and molecular oxygen concentration. The present work deals with the investigation of blood oxygen saturation in vitro and in vivo during light irradiation in the PDT process. It has been observed that SO2 behavior strongly correlates with the light power density applied for PDT and photosensitizer concentration.

Citation Download Citation

Alexander A. Stratonnikov, Alexandre Yu. Douplik, D. V. Klimov, Victor B. Loschenov, and S. V. Mizin "Influence of light irradiation on blood oxygen saturation level in vitro and in vivo during photodynamic therapy", Proc. SPIE 3247, Optical Methods for Tumor Treatment and Detections: Mechanisms and Techniques in Photodynamic Therapy VII, (19 May 1998); https://doi.org/10.1117/12.308140

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