Autofluorescence of tissue surrounding malignant tumors

Wolfgang Lohmann; Rainer M. Bohle; Wolf-Bernhard Schill; H. Vahrson; J. Mussmann

doi:10.1117/12.306049

24 April 1998 Autofluorescence of tissue surrounding malignant tumors

Wolfgang Lohmann, Rainer M. Bohle, Wolf-Bernhard Schill, H. Vahrson, J. Mussmann

Proceedings Volume 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II; (1998) https://doi.org/10.1117/12.306049
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

In vitro fluorescence measurements on pap smears of ascites, pleura, or Douglas confirmed results obtained previously with different types of tissue: Cancer tissue fluoresces hardly and is surrounded by a 'fluorescence belt.' Investigations of cytological smears (e.g. Pap smears) have revealed the possible participation of granulocytes in this 'immune' reaction. Furthermore, there seems to be obvious differences in the fluorescence response of pap smears between ovarial- carcinomas and peritoneal carcinomas based on ovarial carcinoma. This observation cannot be explained yet. Because of its sensitivity and specificity the fluorescence method can be used as an additional tool for the evaluation of the tumor invasion front. Preferably it might be used for frozen sections of biopsies and surgical excisions.

Citation Download Citation

Wolfgang Lohmann, Rainer M. Bohle, Wolf-Bernhard Schill, H. Vahrson, and J. Mussmann "Autofluorescence of tissue surrounding malignant tumors", Proc. SPIE 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II, (24 April 1998); https://doi.org/10.1117/12.306049

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