Application of laser Raman spectroscopy in concentration measurements of multiple analytes in human body fluids

Jianan Y. Qu; David Suria; Brian C. Wilson

doi:10.1117/12.308044

1 May 1998 Application of laser Raman spectroscopy in concentration measurements of multiple analytes in human body fluids

Jianan Y. Qu, David Suria, Brian C. Wilson

Author Affiliations +

Proceedings Volume 3253, Biomedical Sensing and Imaging Technologies; (1998) https://doi.org/10.1117/12.308044
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

The primary goal of these studies was to demonstrate that NIR Raman spectroscopy is feasible as a rapid and reagentless analytic method for clinical diagnostics. Raman spectra were collected on human serum and urine samples using a 785 nm excitation laser and a single-stage holographic spectrometer. A partial east squares method was used to predict the analyte concentrations of interest. The actual concentrations were determined by a standard clinical chemistry. The prediction accuracy of total protein, albumin, triglyceride and glucose in human sera ranged from 1.5 percent to 5 percent which is greatly acceptable for clinical diagnostics. The concentration measurements of acetaminophen, ethanol and codeine inhuman urine have demonstrated the potential of NIR Raman technology in screening of therapeutic drugs and substances of abuse.

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Jianan Y. Qu, David Suria, and Brian C. Wilson "Application of laser Raman spectroscopy in concentration measurements of multiple analytes in human body fluids", Proc. SPIE 3253, Biomedical Sensing and Imaging Technologies, (1 May 1998); https://doi.org/10.1117/12.308044

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