Pressure generation in melanosomes by subnanosecond laser pulses

Jinming Sun; Bernard S. Gerstman

doi:10.1117/12.308161

13 May 1998 Pressure generation in melanosomes by subnanosecond laser pulses

Jinming Sun, Bernard S. Gerstman

Proceedings Volume 3254, Laser-Tissue Interaction IX; (1998) https://doi.org/10.1117/12.308161
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

We have computationally modeled the generation of high pressures in melanosomes resulting from the absorption of sub- nanosecond laser pulses. The melanosome is treated as a solid sphere characterized by a bulk modulus, specific heat, coefficient of thermal expansion, and a uniform absorption coefficient. Using a series of partial differential equations to represent how the absorbed laser energy is converted to thermal and mechanical energy, we can calculate expected pressures resulting from laser pulses of any duration or fluence. We find that for the same fluence, the maximum pressure generated increases as the pulse duration decreases. For sub-nanosecond pulses, kilobar pressures can be generated inside the melanosome. We examine how the pressures that are generated depend on pulse characteristics and melanosome properties.

Citation Download Citation

Jinming Sun and Bernard S. Gerstman "Pressure generation in melanosomes by subnanosecond laser pulses", Proc. SPIE 3254, Laser-Tissue Interaction IX, (13 May 1998); https://doi.org/10.1117/12.308161

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