Discrimination and quantitation using IR spectra: novel methods for serum analysis and for cervical dysplasia screening

R. A. Shaw; M. Leroux; M. Paraskevas; F. B. Guijon; S. Kotowich; Henry H. Mantsch

doi:10.1117/12.306091

24 April 1998 Discrimination and quantitation using IR spectra: novel methods for serum analysis and for cervical dysplasia screening

R. A. Shaw, M. Leroux, M. Paraskevas, F. B. Guijon, S. Kotowich, Henry H. Mantsch

Author Affiliations +

Proceedings Volume 3257, Infrared Spectroscopy: New Tool in Medicine; (1998) https://doi.org/10.1117/12.306091
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

IR spectroscopy shows the promise of developing into a clinically relevant methodology for both screening and quantitative applications. The principles are straightforward - the IR spectrum of appropriate biological fluids or tissues may be interpreted to reveal diagnostic information either directly through inspection, or indirectly through the use of appropriate classification or quantitation algorithms. Implementing these methods in practice is not as straightforward. This report summarizes our experiences to date in developing methods for the quantitation of several serum analytes from the IR spectra of dried serum films, and for the IR-based detection/grading of abnormalities in exfoliated cervical cell specimens.

Citation Download Citation

R. A. Shaw, M. Leroux, M. Paraskevas, F. B. Guijon, S. Kotowich, and Henry H. Mantsch "Discrimination and quantitation using IR spectra: novel methods for serum analysis and for cervical dysplasia screening", Proc. SPIE 3257, Infrared Spectroscopy: New Tool in Medicine, (24 April 1998); https://doi.org/10.1117/12.306091

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