Probing diseased skin with FT-Raman spectroscopy

Elizabeth A. Carter; Adrian C. Williams; Brian W. Barry; Howell G.M. Edwards

doi:10.1117/12.306085

24 April 1998 Probing diseased skin with FT-Raman spectroscopy

Elizabeth A. Carter, Adrian C. Williams, Brian W. Barry, Howell G.M. Edwards

Proceedings Volume 3257, Infrared Spectroscopy: New Tool in Medicine; (1998) https://doi.org/10.1117/12.306085
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Healthy and abnormal human skin has been examined using Fourier transform (FT) Raman spectroscopy. The molecular basis of alternations in this tissue have been proved with the aim of providing a tool to aid in clinical diagnosis of skin disorders. Intact human stratum corneum show spectral features of keratin and the lipids. Spectra from callus and psoriatic tissue show that the keratin component is essentially intact and is similar to that in the normal tissue. However, the abnormal skin shows that the keratin component is essentially intact and is similar to that in the normal tissue. However, the abnormal skin shows a significant depletion of the lipoidal component, which correlates with clinical observations of an increase in permeability and the hyper-proliferative nature of these conditions. Verrucal tissue again shows some alterations to the lipoidal fraction of the tissue.

Citation Download Citation

Elizabeth A. Carter, Adrian C. Williams, Brian W. Barry, and Howell G.M. Edwards "Probing diseased skin with FT-Raman spectroscopy", Proc. SPIE 3257, Infrared Spectroscopy: New Tool in Medicine, (24 April 1998); https://doi.org/10.1117/12.306085

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available