Automated assessment of split lung functon in post-lung-transplant evaluation

Jonathan G. Goldin; Matthew S. Brown; Michael F. McNitt-Gray; Lloyd E. Greaser; Katherine Martin; James W. Sayre; Denise R. Aberle

doi:10.1117/12.312573

3 July 1998 Automated assessment of split lung functon in post-lung-transplant evaluation

Jonathan G. Goldin, Matthew S. Brown, Michael F. McNitt-Gray, Lloyd E. Greaser, Katherine Martin, James W. Sayre, Denise R. Aberle

Author Affiliations +

Proceedings Volume 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images; (1998) https://doi.org/10.1117/12.312573
Event: Medical Imaging '98, 1998, San Diego, CA, United States

Abstract

The purpose of this work was to develop an automated technique for calculating dynamic lung attenuation changes, through a forced expiratory maneuver, as a measure of split lung function. A total of ten patients post single lung transplantation (SLT) for emphysema were imaged using an Electron Beam CT Scanner; three were studied twice following stent placement. A single-slice flow study, using 100 msec exposures and 3 mm collimation, was performed at the level of the anastomosis during a forced expiration. Images were acquired every 500 msec for the first 3 seconds and every second for the last 4 seconds. An automated, knowledge-based system was developed to segment the chest wall, mediastinum, large airways and lung parenchyma in each image. Knowledge of the expected size, shape, topology and X-ray attenuation of anatomical structures were used to guide image segmentation involving attenuation thresholding, region-growing and morphology. From the segmented left and right parenchyma, the system calculated median attenuation (HU) and cross-sectional areas. These results were plotted against time for both the native and transplanted lungs. In five patients, significant shift of the attenuation/time curve to the right (slower flow) was detected, although the end expiration attenuation was not different. Following stent placement the curve shifted back to the left (faster flow).

Citation Download Citation

Jonathan G. Goldin, Matthew S. Brown, Michael F. McNitt-Gray, Lloyd E. Greaser, Katherine Martin, James W. Sayre, and Denise R. Aberle "Automated assessment of split lung functon in post-lung-transplant evaluation", Proc. SPIE 3337, Medical Imaging 1998: Physiology and Function from Multidimensional Images, (3 July 1998); https://doi.org/10.1117/12.312573

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