Functional analysis of tumor cell growth and clearance in living animals

Thomas J. Sweeney; Volker Mailaender; Amanda A. Tucker; Adesuwa B. Olomu; Weisheng Zhang; Robert S. Negrin M.D.; Christopher H. Contag

doi:10.1117/12.351023

2 July 1999 Functional analysis of tumor cell growth and clearance in living animals

Thomas J. Sweeney, Volker Mailaender, Amanda A. Tucker, Adesuwa B. Olomu, Weisheng Zhang, Robert S. Negrin M.D., Christopher H. Contag

Author Affiliations +

Proceedings Volume 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation; (1999) https://doi.org/10.1117/12.351023
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Evaluation of antineoplastic therapies would be enhanced by sensitive methods that noninvasively asses both tumor location and neoplastic growth kinetics in living animals. Since light is transmitted through mammalian tissues, it was possible to externally monitor growth and regression of luciferase labeled murine tumor cells engrafted into immunodeficient mice. External quantification of tumor burden revealed the biological impact of the chemotherapeutic agent cyclophosphamide on the kinetics of tumor growth in living animals. Therapeutic activity was apparent but this drug did not eliminate the NIH 3T3 cell signal over the 28 d time course. This novel, noninvasive system allowed sensitive, real time spatiotemporal analyses of neoplastic cell growth and may facilitate rapid optimization of effective therapeutic treatment regimes.

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Thomas J. Sweeney, Volker Mailaender, Amanda A. Tucker, Adesuwa B. Olomu, Weisheng Zhang, Robert S. Negrin M.D., and Christopher H. Contag "Functional analysis of tumor cell growth and clearance in living animals", Proc. SPIE 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation, (2 July 1999); https://doi.org/10.1117/12.351023

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