Cavitation thresholds in the rabbit retinal pigmented epithelium

Dale J. Payne; Thomas R. Jost; James J. Elliot; Brent Eilert; Laura Lott; Karen Lott; Gary D. Noojin; Richard A. Hopkins Jr.; Charles P. Lin; Benjamin A. Rockwell

doi:10.1117/12.350019

14 June 1999 Cavitation thresholds in the rabbit retinal pigmented epithelium

Dale J. Payne, Thomas R. Jost, James J. Elliot, Brent Eilert, Laura Lott, Karen Lott, Gary D. Noojin, Richard A. Hopkins Jr., Charles P. Lin, Benjamin A. Rockwell

Author Affiliations +

Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.350019
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

We performed measurements to examine retinal injury from laser pulses in the sub-nanosecond time regime. Both ex-vivo porcine and Dutch belted rabbit retinal pigment epithelium (RPE) models were used in conjunction with time resolved imaging to observe cavitation bubble formation. Included in this study are 3 ps, 300 fs, and 100 fs pulses at a wavelength of 580 nm, as well as 70 ps and 5 ns pulses at 532 nm. Threshold values varied between 37 mJ/cm² and 50 mJ/cm² across the range of pulse widths. Following laser irradiation cell viability was checked using a fluorescent dye marker (calcein). Our current results are compared to an earlier investigation using the artificial retina model.

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Dale J. Payne, Thomas R. Jost, James J. Elliot, Brent Eilert, Laura Lott, Karen Lott, Gary D. Noojin, Richard A. Hopkins Jr., Charles P. Lin, and Benjamin A. Rockwell "Cavitation thresholds in the rabbit retinal pigmented epithelium", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); https://doi.org/10.1117/12.350019

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