Elastic scattering spectroscopy in vivo: optical biopsies of cancers of the breast and GI tract

David Christopher O. Pickard; Gavin M. Briggs; Christobel Saunders; Sunil Lakhani; Paul M. Ripley; Irving J. Bigio; Stephen G. Bown

doi:10.1117/12.382717

19 April 2000 Elastic scattering spectroscopy in vivo: optical biopsies of cancers of the breast and GI tract

David Christopher O. Pickard, Gavin M. Briggs, Christobel Saunders, Sunil Lakhani, Paul M. Ripley, Irving J. Bigio, Stephen G. Bown

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Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382717
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Elastic scattering or diffuse reflectance spectroscopy offers the possibility of distinguishing between normal and neoplastic tissue with a relatively simple optical measurement. The measurement of the reflection of light has previously been shown to be sensitive to the size and distribution of both intra and inter-cellular structures as well as absorption from chromatophores which are present in the tissue. By coupling a white light source and spectrometer to optic fibers it is possible to construct probes which can be inserted precutaneously or intra- operatively into breast tissue or which can pass down the channel of an endoscope and take in-vivo spectra of diseased and normal tissue in the Gastro-Intestinal tract. Spectra are reported from a large number of patients with a variety of benign, metaplastic, dysplastic and cancerous conditions. Some differences that have been observed in these spectra are discussed and the merits and disadvantages of 'optical biopsy' as an in-vivo diagnostic tool are examined. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish cancerous from normal tissue in a number of cases. The methods of distinguishing spectra and some possible modalities for their improvement are discussed.

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David Christopher O. Pickard, Gavin M. Briggs, Christobel Saunders, Sunil Lakhani, Paul M. Ripley, Irving J. Bigio, and Stephen G. Bown "Elastic scattering spectroscopy in vivo: optical biopsies of cancers of the breast and GI tract", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382717

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KEYWORDS

Biopsy

Tissues

Tissue optics

Breast

Scattering

Spectroscopy

Breast cancer

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