New continuous polymeric surfaces for spot-synthesis, combinatorial chemistry, compound libraries, and high throughput applications

Marco Schulz; Uwe Schedler; Heike Matuschewski; Holger Wenschuh

doi:10.1117/12.411722

29 December 2000 New continuous polymeric surfaces for spot-synthesis, combinatorial chemistry, compound libraries, and high-throughput applications

Marco Schulz, Uwe Schedler, Heike Matuschewski, Holger Wenschuh

Author Affiliations +

Proceedings Volume 4200, Biochemical and Biomolecular Sensing; (2000) https://doi.org/10.1117/12.411722
Event: Environmental and Industrial Sensing, 2000, Boston, MA, United States

Abstract

Solid phase synthesis, especially spot-synthesis on cellulose membranes is well established for facile preparation of large arrays of biomolecules, e.g. peptides, nucleic acids, peptoides and the subsequent solid and solution phase, screening. Despite many good properties of cellulose membranes for some applications this material has a number of limitations such as low chemical and mechanical stability and high concentration of reactive, chemical different hydroxyl groups causing side reactions. Therefore a novel continuous polymeric material, porous membranes and non-porous materials, was developed based on the chemical and photochemical surface functionalization by grafting of flexible polymer chains carrying the functional and reactive groups for the syntheses. Several classes of compounds e.g. peptides, nucleic acids, peptoides, glucoconjugates and small organic molecules were synthesized using the new continuous polymeric surface.

Citation Download Citation

Marco Schulz, Uwe Schedler, Heike Matuschewski, and Holger Wenschuh "New continuous polymeric surfaces for spot-synthesis, combinatorial chemistry, compound libraries, and high-throughput applications", Proc. SPIE 4200, Biochemical and Biomolecular Sensing, (29 December 2000); https://doi.org/10.1117/12.411722

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