ICDC interstitial ultrasound applicators for high-temperature thermal therapy

Per Daniel Tyreus; Chris J. Diederich; William H. Nau

doi:10.1117/12.427848

1 June 2001 ICDC interstitial ultrasound applicators for high-temperature thermal therapy

Per Daniel Tyreus, Chris J. Diederich, William H. Nau

Proceedings Volume 4247, Thermal Treatment of Tissue: Energy Delivery and Assessment; (2001) https://doi.org/10.1117/12.427848
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Theoretical and experimental approaches were used to evaluate Internally-Cooled Direct-Coupled (ICDC) ultrasound applicators for treating disease in the prostate and liver. 2-D and 3-D transient biothermal models, which account for dynamic tissue changes, were used to calculate temperature distributions and zones of coagulation. Experimental evaluations and verification of these models were performed using in vitro tissue and in vivo porcine and canine models. Devices of 2.2 mm outer diameter were evaluated under varied applied power schemes and cooling levels. Both duty cycle power application and PI-controlled power application were found to improve applicator performance by increasing radial depths of lesions with lower maximum temperature. ICDC applicators were found to be able to create 3-5 cm diameter lesions in liver and muscle under 15 minute treatment times using the optimal designs and power application schemes found in this study. From these initial feasibility studies it has been demonstrated that ICDC devices have potential for treating cancerous tumors in prostate, liver and possibly breast.

Citation Download Citation

Per Daniel Tyreus, Chris J. Diederich, and William H. Nau "ICDC interstitial ultrasound applicators for high-temperature thermal therapy", Proc. SPIE 4247, Thermal Treatment of Tissue: Energy Delivery and Assessment, (1 June 2001); https://doi.org/10.1117/12.427848

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