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We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show volumetric spatial changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying vascular tissues.
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Avraham Bluestone, Gassan S. Abdoulaev, Randall Locke Barbour, Christoph H. Schmitz, Andreas H. Hielscher, "Three-dimensional optical tomographic localization of changes in absorption coefficients in the human brain," Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434496