Effect of fiber optic probe design on fluorescent light propagation in tissue

T. Joshua Pfefer; Kevin T. Schomacker; Norman S. Nishioka

doi:10.1117/12.434727

9 July 2001 Effect of fiber optic probe design on fluorescent light propagation in tissue

T. Joshua Pfefer, Kevin T. Schomacker, Norman S. Nishioka

Proceedings Volume 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical; (2001) https://doi.org/10.1117/12.434727
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Fiber optic probes used to deliver and collect light for biomedical fluorescence spectroscopy applications have varied widely in design. Critical design parameters include fiber diameter, tissue fiber-tip spacing, and illumination- collection fiber separation distance. While device design has been shown to influence spectral distributions, previous studies have not thoroughly addressed how probe geometry affects the spatial origin of detected fluorescence or how probe design might be customized for specific tissue sites or applications. We have developed a Monte Carlo model of laser-induced fluorescence and investigated the effect of design parameters on light propagation using gastrointestinal tissue optical properties. The distribution of emission locations for detected fluorescence were calculated. Initial results indicated that average fluorescence emission depth and total signal intensity are highly dependent on fiber size and tissue-fiber spacing. The implications of these results for optimization of probes used in the detection of neoplasia are discussed.

Citation Download Citation

T. Joshua Pfefer, Kevin T. Schomacker, and Norman S. Nishioka "Effect of fiber optic probe design on fluorescent light propagation in tissue", Proc. SPIE 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, (9 July 2001); https://doi.org/10.1117/12.434727

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available