Automatic temporal subtraction of chest radiographs and its enhancement for lung cancers

Hui Zhao; Shih-Chung Benedict Lo; Matthew T. Freedman M.D.; Seong Ki Mun

doi:10.1117/12.431078

3 July 2001 Automatic temporal subtraction of chest radiographs and its enhancement for lung cancers

Hui Zhao, Shih-Chung Benedict Lo, Matthew T. Freedman M.D., Seong Ki Mun

Proceedings Volume 4322, Medical Imaging 2001: Image Processing; (2001) https://doi.org/10.1117/12.431078
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

In this study, we demonstrate an approach of using automatic edge detection and registration techniques for the temporal subtraction of chest radiographs. We also show that the contrasts of lung cancers were greatly enhanced. Difference images were obtained by subtracting an earlier chest radiograph from the later chest radiograph of the same patient. Prior to the subtraction, the lung areas were extracted by a convolution neural network. Segmented lungs and rib cages on both images were used to perform registration using directional edge extractors. Control points were selected prior to a warping process for the final registration. We also investigated the contrast enhancement of the lung cancer by analyzing the local area on the images. The signal-to-noise ratios at each cancer location were compared to evaluate the degree of improvement between the later chest image and the subtraction image. Our results indicated that the average signal-to-noise ratios at cancer locations were increased from 50% to 80%. The selected cases were collected for this study based on their subtleness. For each of this case, at least 4 radiologists out of 15 radiologists missed the cancer with a mean at 7.2 radiologists resulting from a recent observer study.

Citation Download Citation

Hui Zhao, Shih-Chung Benedict Lo, Matthew T. Freedman M.D., and Seong Ki Mun "Automatic temporal subtraction of chest radiographs and its enhancement for lung cancers", Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); https://doi.org/10.1117/12.431078

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