Trimodal spectroscopy as a tool for detecting cervical squamous intraepithelial lesions in vivo

Irene Georgakoudi; Ellen E. Sheets; Christopher P. Crum; Markus G. Mueller; Vadim Backman; Michael S. Feld

doi:10.1117/12.447118

31 October 2001 Trimodal spectroscopy as a tool for detecting cervical squamous intraepithelial lesions in vivo

Irene Georgakoudi, Ellen E. Sheets, Christopher P. Crum, Markus G. Mueller, Vadim Backman, Michael S. Feld

Proceedings Volume 4432, Diagnostic Optical Spectroscopy in Biomedicine; (2001) https://doi.org/10.1117/12.447118
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.

Citation Download Citation

Irene Georgakoudi, Ellen E. Sheets, Christopher P. Crum, Markus G. Mueller, Vadim Backman, and Michael S. Feld "Trimodal spectroscopy as a tool for detecting cervical squamous intraepithelial lesions in vivo", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); https://doi.org/10.1117/12.447118

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