DNA binding of supramolecular mixed-metal complexes

Shawn Swavey; Rodd Lee Williams; Zhenglai Fang; Matthew Milkevitch; Karen Jenks Brewer

doi:10.1117/12.446779

23 October 2001 DNA binding of supramolecular mixed-metal complexes

Shawn Swavey, Rodd Lee Williams, Zhenglai Fang, Matthew Milkevitch, Karen Jenks Brewer

Proceedings Volume 4512, Complex Adaptive Structures; (2001) https://doi.org/10.1117/12.446779
Event: Complex Adaptive Structures, 2001, Hutchinson Island, FL, United States

Abstract

The high binding affinity of cisplatin toward DNA has led to its popularity as an anticancer agent. Due to cumulative drug resistance and toxic side effects, researchers are exploring related metallodrugs. Our approach involves the use of supramolecular complexes. These mixed-metal complexes incorporate a reactive platinum moiety bridged by a polyazine ligand to a light absorbing metal-based chromophore. The presence of the light absorber allows excitation of these systems, opening up the possibility of photoactivation. The use of a supramolecular design allows components of the assembly to be varied to enhance device function and light absorbing properties. Aspects of our molecular design process and results on the DNA binding properties for a number of these mixed-metal complexes will be discussed.

Citation Download Citation

Shawn Swavey, Rodd Lee Williams, Zhenglai Fang, Matthew Milkevitch, and Karen Jenks Brewer "DNA binding of supramolecular mixed-metal complexes", Proc. SPIE 4512, Complex Adaptive Structures, (23 October 2001); https://doi.org/10.1117/12.446779

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