Application of laser speckle interferometry for monitoring the dynamics of lymph flow

Haiying Cheng; Qingming Luo; Zheng Wang; Lei Yao; Sergey S. Ulyanov; Ekateryna I. Zakharova; Shaoqun Zeng

doi:10.1117/12.462538

12 April 2002 Application of laser speckle interferometry for monitoring the dynamics of lymph flow

Haiying Cheng, Qingming Luo, Zheng Wang, Lei Yao, Sergey S. Ulyanov, Ekateryna I. Zakharova, Shaoqun Zeng

Proceedings Volume 4536, International Workshop on Photonics and Imaging in Biology and Medicine; (2002) https://doi.org/10.1117/12.462538
Event: International Workshop on Photonics and Imaging in Biology and Medicine, 2001, Wuhan, China

Abstract

This paper applied the zero-crossings of laser speckle (ZCLS) method, utilizing the diffraction of a focused Gaussian beam, to obtain the dynamics of lymph flow on the rat mesentery in vivo. Two experiments were designed in this study: one was the intralipid model experiment; and the other was the lymph flow under the influence of isoprenaline. In the former, the temporal dynamics of intralipid flow were acquired indicating the validity of the ZCLS method. In the latter, the speckle interferometry results manifested no significant changes in the average velocities of lymph flow, which was consistent with the result obtained by the conventional physiological method of frame by frame analysis. However, the speckle results also manifested that the lymph flow dynamics changed under the drug's influence, which could not be gained by the conventional physiological methods. These indicated that the speckle interferometry technique was promising to determine lymph-flow diagnostics.

Citation Download Citation

Haiying Cheng, Qingming Luo, Zheng Wang, Lei Yao, Sergey S. Ulyanov, Ekateryna I. Zakharova, and Shaoqun Zeng "Application of laser speckle interferometry for monitoring the dynamics of lymph flow", Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); https://doi.org/10.1117/12.462538

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