Tumor detection with sonodynamic chemiluminescence from ATX-70 and FCLA under ultrasonic excitation

Yonghong He; Da Xing; Yong Yao; Guihong Yan; Ken-ichi Ueda

doi:10.1117/12.469348

6 June 2002 Tumor detection with sonodynamic chemiluminescence from ATX-70 and FCLA under ultrasonic excitation

Yonghong He, Da Xing, Yong Yao, Guihong Yan, Ken-ichi Ueda

Proceedings Volume 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI; (2002) https://doi.org/10.1117/12.469348
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

A new tumor detection method by use of sonodynamic chemiluminescence was proposed in our previous work. In this paper, we further improved the diagnosis sensitivity by use of Gallium-porphyrin analogue ATX-70, one of the most active sonosensitizer found. In vitro experiments, sono-chemiluminescence of ATX-70 + FCLA system is about two times stronger than that of HpD + FCLA system. The sono-chemiluminescence was inhibited by ¹O₂ scavenger, but was not affected by other free radical scavenger. The mechanism of sonosensitizing was discussed. In vivo experiments, a more clearly tumor diagnostic image was obtained.

Citation Download Citation

Yonghong He, Da Xing, Yong Yao, Guihong Yan, and Ken-ichi Ueda "Tumor detection with sonodynamic chemiluminescence from ATX-70 and FCLA under ultrasonic excitation", Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); https://doi.org/10.1117/12.469348

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