Hollow-waveguide-based laser-to-ultrasound transducer for drug delivery application

Shunichi Sato; Makoto Ogura; Minoru Obara; Yi-Wei Shi; Yuji Matsuura; Mitsunobu Miyagi; Hiroshi Ashida

doi:10.1117/12.463814

26 March 2002 Hollow-waveguide-based laser-to-ultrasound transducer for drug delivery application

Shunichi Sato, Makoto Ogura, Minoru Obara, Yi-Wei Shi, Yuji Matsuura, Mitsunobu Miyagi, Hiroshi Ashida

Proceedings Volume 4616, Optical Fibers and Sensors for Medical Applications II; (2002) https://doi.org/10.1117/12.463814
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

A COP (cyclic olefin polymer)-coated silver hollow waveguide was used to transmit 1064-nm nanosecond laser pulses that irradiated a metal target to produce an ultrasound wave (stress wave) through plasma formation on the target. Porcine gastric and myocardium tissues, on which a solution of rhodamine-B isothiocyanate-dextran (10 kDa) was dropped, were exposed to the stress wave. Much deeper drug penetration was observed for the tissues exposed the stress wave than for the tissues without stress wave exposure.

Citation Download Citation

Shunichi Sato, Makoto Ogura, Minoru Obara, Yi-Wei Shi, Yuji Matsuura, Mitsunobu Miyagi, and Hiroshi Ashida "Hollow-waveguide-based laser-to-ultrasound transducer for drug delivery application", Proc. SPIE 4616, Optical Fibers and Sensors for Medical Applications II, (26 March 2002); https://doi.org/10.1117/12.463814

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