Animal model of photodynamic-therapy-induced esophageal stricture: preliminary report

Yaron Perry M.D.; Michael W. Epperly; Sydney Finkelstein M.D.; Edwin Klein V.D.M.; Joel Greenberger M.D.; James Luketich M.D.

doi:10.1117/12.485327

12 September 2003 An animal model of photodynamic-therapy-induced esophageal stricture: preliminary report

Yaron Perry M.D., Michael W. Epperly, Sydney Finkelstein M.D., Edwin Klein V.D.M., Joel Greenberger M.D., James Luketich M.D.

Author Affiliations +

Proceedings Volume 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII; (2003) https://doi.org/10.1117/12.485327
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Photodynamic Therapy (PDT) using Photofrin has been recently approved by the FDA for the treatment of esophageal cancer and Barrett's esophagus. A major limitation of PDT for Barrett's esophagus is the development of esophageal stricture in up to 53% of patients. Mechanisms of PDT stricture formation have not been elucidated. The major difficulty is the lack of an animal model for PDT-induced stricture. We have used a pig model in which the esophagus is very similar to that of the human esophagus. Two (Scrofa) domestic pigs were injected with Photofrin at dosage of 2 mg/kg 48 hours prior to photoactivation with 630 nm light. Following anesthesia, a laser probe (2.5 cm in length) was passed through the oral cavity to approximately the mid-point of the esophagus via an endoscope. Light energy (400 Joules (J)/cm) was delivered as a single dose in one pig or repeated at 72 hours in the second pig. In this pig model, upper endoscopy, Barium swallow and pathological studies confirmed stricture formation following esophageal PDT exposure of 400 J as one or two fractions. We believe that this is the first animal model created to study esophageal strictures resulting from PDT.

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Yaron Perry M.D., Michael W. Epperly, Sydney Finkelstein M.D., Edwin Klein V.D.M., Joel Greenberger M.D., and James Luketich M.D. "An animal model of photodynamic-therapy-induced esophageal stricture: preliminary report", Proc. SPIE 4949, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII, (12 September 2003); https://doi.org/10.1117/12.485327

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KEYWORDS

Photodynamic therapy

Esophagus

Animal model studies

Endoscopy

Lung

Barium

Endoscopes

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