Increasing oxygenation and radiation sensitivity following photodynamic therapy with verteporfin in the RIF-1 tumor

Brian W. Pogue; Julia A. O'Hara; Eugene Demidenko; Carmen M. Wilmot; Bin Chen; Harold M. Swartz; Tayyaba Hasan

doi:10.1117/12.473594

13 June 2003 Increasing oxygenation and radiation sensitivity following photodynamic therapy with verteporfin in the RIF-1 tumor

Brian W. Pogue, Julia A. O'Hara, Eugene Demidenko, Carmen M. Wilmot, Bin Chen, Harold M. Swartz, Tayyaba Hasan

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Proceedings Volume 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII; (2003) https://doi.org/10.1117/12.473594
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

The combination of verteporfin-based photodynamic therapy (PDT) wiht radiaiton therapy from an orthovoltage device has been examiend in the radiation induced fibrosarcoma tumor model. PDT with verteporfin using a 3 hour delay between injection and the time of optical irradiation has been shown to cause a significant rise in overlal tumor oxygenation. It was huypothesized that this mechanism arises from the reduced oxygen consumption from cells where the PDT has targeted the mitochondria and shut down cellular respiration. Tumor blood flow was measured and found to be still be patent immediately following therapy. This increasing oxygenation was thought to provide an opportunity to increase the radiation sensitivity of the tumor immediately following PDT. When this type of treatment was combined with radiation therapy, a delay in the tumor regrowth time demonstrated that the combined effect was greater than additive. Further study of this phenomenon will provide a more complete mechanistic understanding of the effect and possibly provide a viable pre-treatment for radiation therapy of tumore that increases the therapeutic ratio. This effect could be used to either increase the radiaton dose without increasing the side effects or decrease the dose needed for the same effect on the tumor.

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Brian W. Pogue, Julia A. O'Hara, Eugene Demidenko, Carmen M. Wilmot, Bin Chen, Harold M. Swartz, and Tayyaba Hasan "Increasing oxygenation and radiation sensitivity following photodynamic therapy with verteporfin in the RIF-1 tumor", Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); https://doi.org/10.1117/12.473594

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KEYWORDS

Tumors

Photodynamic therapy

Blood circulation

Radiotherapy

Oxygen

Radiation effects

Tissues

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