Ultrasensitive diode-laser-based monitor for singlet oxygen

Steven J. Davis; Leyun Zhu; Ahmed M. Minhaj; Michael F. Hinds; Seonkyung Lee; Philip B. Keating; David I. Rosen; Tayyaba Hasan

doi:10.1117/12.479433

13 June 2003 Ultrasensitive diode-laser-based monitor for singlet oxygen

Steven J. Davis, Leyun Zhu, Ahmed M. Minhaj, Michael F. Hinds, Seonkyung Lee, Philip B. Keating, David I. Rosen, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII; (2003) https://doi.org/10.1117/12.479433
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

In this paper we present results from experiments to develop a real-time, optical monitor for singlet molecular oxygen produced during photodynamic therapy. Using a pulsed diode laser and a sensitive photomultiplier tube, we have obtained signals from singlet oxygen during and following pulsed laser excitation. Several photosensitizers were used, and we obtained strong signals even in the presence of protein laden environments. Values obtained for the lifetimes of the singlet oxygen state and the photosensitizer triplet state are compared to literature values.

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Steven J. Davis, Leyun Zhu, Ahmed M. Minhaj, Michael F. Hinds, Seonkyung Lee, Philip B. Keating, David I. Rosen, and Tayyaba Hasan "Ultrasensitive diode-laser-based monitor for singlet oxygen", Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); https://doi.org/10.1117/12.479433

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