Histologic differences between cryothermic and hyperthermic therapies

James E. Coad M.D.; John C. Bischof

doi:10.1117/12.476334

10 June 2003 Histologic differences between cryothermic and hyperthermic therapies

James E. Coad M.D., John C. Bischof

Proceedings Volume 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II; (2003) https://doi.org/10.1117/12.476334
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Minimally invasive cryothermic and hyperthermic therapies are being increasingly used to destroy dysfunctional and neoplastic tissues in several organ systems. This report morphologically compares the acute tissue response that follow cryothermic and microwave therapy in porcine kidneys. Three cryothermic and hyperthermic groups of treated kidneys were pooled from other studies for evaluation: 1) in vitro treated non-perfused, 2) in situ treated with 2-hour post in vivo perfusion, and 3) in situ treated with 3-day or 7-day post in vivo perfusion. The cryolesions showed uniform central coagulative-type necrosis and interstitial hemorrhage. The hyperthermic lesions showed central thermal fixation and a rim of coagulative necrosis. The cryothermic and hyperthermic lesions both had a similar narrow transition zone of partial cell injury. The cryothermic lesions developed a wound healing response that advanced into the central lesion. In contrast, the heat-treated tissues lacked a prominent wound healing response and appeared to resist breakdown/repair by the body. Thus, the tissue effects of and response to cryothermic and heat injury appear to be different.

Citation Download Citation

James E. Coad M.D. and John C. Bischof "Histologic differences between cryothermic and hyperthermic therapies", Proc. SPIE 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II, (10 June 2003); https://doi.org/10.1117/12.476334

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available