Identification of missed pulmonary nodules on low-dose CT lung cancer screening studies using an automatic detection system

Carol L. Novak; Li Fan; Jianzhong Qian; Guo-Qing Wei; David P. Naidich M.D.

doi:10.1117/12.480101

22 May 2003 Identification of missed pulmonary nodules on low-dose CT lung cancer screening studies using an automatic detection system

Carol L. Novak, Li Fan, Jianzhong Qian, Guo-Qing Wei, David P. Naidich M.D.

Author Affiliations +

Proceedings Volume 5034, Medical Imaging 2003: Image Perception, Observer Performance, and Technology Assessment; (2003) https://doi.org/10.1117/12.480101
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

Multi-slice CT (MSCT) scanners allow nodules as small as 3mm to be identified during screening. However the associated large data sets make it challenging for radiologists to identify all small nodules in a reasonable amount of time. Computer-aided detection may play a critical role in identifying missed nodules. 13 MSCT screening studies, initially interpreted as "non-actionable" by a radiologist, were selected from participants in a lung cancer screening study. The study protocol defines "actionable" studies as those containing at least 1 solid non-calcified nodule larger than 3mm, for which follow-up studies are recommended to exclude interval growth. An automatic detection algorithm was applied to the 13 studies to determine whether it might detect missed nodules, and whether any of these were of sufficient size to be considered "actionable". There were a total of 138 automatically detected candidate nodules, an average of 10.6 per patient. 83 candidates were characterized as true positives, yielding a positive predictive value of 60.1%. 10 automatically detected candidates were judged to be actionable nodules greater than 3mm in diameter. 6 of 13 (46%) patients had at least one "actionable" finding detected by the computer that had been overlooked in the initial exam.

Citation Download Citation

Carol L. Novak, Li Fan, Jianzhong Qian, Guo-Qing Wei, and David P. Naidich M.D. "Identification of missed pulmonary nodules on low-dose CT lung cancer screening studies using an automatic detection system", Proc. SPIE 5034, Medical Imaging 2003: Image Perception, Observer Performance, and Technology Assessment, (22 May 2003); https://doi.org/10.1117/12.480101

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available