Estimation of prediagnostic duration of type 2 diabetes mellitus by lens autofluorometry

Line Kessel; Charlotte Glumer; Michael Larsen M.D.

doi:10.1117/12.500016

8 October 2003 Estimation of prediagnostic duration of type 2 diabetes mellitus by lens autofluorometry

Line Kessel, Charlotte Glumer, Michael Larsen M.D.

Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.500016
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Type 2 diabetes mellitus is a global epidemic with the number of affected subjects exceeding 4% of the adult population world-wide. Undiagnosed and untreated, the disease results in long-term complications such as myocardial infarction, stroke, and blindness. Treatment reduces the number and severity of long-term complications but treatment is often delayed by a time-lag of 10 years or more from the onset of disease to diagnosis. Earlier diagnosis can be achieved by systematic screening programs but the potential time won is unknown. The aim of the present study was to develop a mathematical model estimating the prediagnostic duration of type 2 diabetes mellitus using lens autofluorescence as an indicator of lifetime glycemic load. Fluorometry of the human is lens a quantitative measurement which is attractive because of the ease by which it can be performed. It is our hope that lens fluorometry will prove useful in estimating the prediagnostic duration of type 2 diabetes mellitus in population studies, a property of profound clinical relevance that is difficult to estimate by any other currently available method.

Citation Download Citation

Line Kessel, Charlotte Glumer, and Michael Larsen M.D. "Estimation of prediagnostic duration of type 2 diabetes mellitus by lens autofluorometry", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.500016

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KEYWORDS

Luminescence

Glucose

Mathematical modeling

Tolerancing

Eye

Proteins

Tissues

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