The study of learning in networks of purified-cultured rat hippocampus neurons

Xiangning Li; Wei Zhou; Ni Sun; Qingming Luo

doi:10.1117/12.546574

8 December 2003 The study of learning in networks of purified-cultured rat hippocampus neurons

Xiangning Li, Wei Zhou, Ni Sun, Qingming Luo

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546574
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

Learning is crucial for brain functioning, especially for hippocampus. To understand the basis of physiological information processing of hippocampus, we developed the networks of purified-cultured rat hippocampus neurons on a planar 60-microelectrode array MEA. We describe how these networks are prepared, their structure, and the forms of spontaneous activity they exhibit. We stimulate the network at a low frequency until a desired predefined response is observed 50- 10 msec after a stimulus, at which point the stimulus is stopped for 5 min. Repeated cycles of this procedure ultimately lead to the desired response being directly elicited by the stimulus. These results demonstrate that there is learning in networks composed of purified-cultured hippocampus neurons.

Citation Download Citation

Xiangning Li, Wei Zhou, Ni Sun, and Qingming Luo "The study of learning in networks of purified-cultured rat hippocampus neurons", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546574

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