Real-time measurement of in-vitro and in-vivo blood flow with Fourier domain optical coherence tomography

Rainer Leitgeb; Leopold Schmetterer; Wolfgang Drexler; Fatmire Berisha; Christoph K. Hitzenberger; Maciej Wojtkowski; Tomasz Bajraszewski; Adolf F. Fercher

doi:10.1117/12.531327

1 July 2004 Real-time measurement of in-vitro and in-vivo blood flow with Fourier domain optical coherence tomography

Rainer Leitgeb, Leopold Schmetterer, Wolfgang Drexler, Fatmire Berisha, Christoph K. Hitzenberger, Maciej Wojtkowski, Tomasz Bajraszewski, Adolf F. Fercher

Author Affiliations +

Proceedings Volume 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII; (2004) https://doi.org/10.1117/12.531327
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We realized an in vivo Fourier domain optical coherence tomography (FD OCT) setup that allows acquiring retinal depth scans at a rate of 25.000 per second. We demonstrate the possibility to measure Doppler flow depth profile in specific regions of interest. The method to extract the flow profiles is based on a local phase analysis of the backscattered signal and allows for bidirectional Doppler flow imaging. The velocity resolution in tissue is 200μm/s. We verified the method by measuring pump controlled in vitro flow through a glass capillary. The system allows for a real-time colour encoded Doppler tomogram rate of 2-4 per second. We recorded the pulsatility of different vessels close to optic nerve head.

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Rainer Leitgeb, Leopold Schmetterer, Wolfgang Drexler, Fatmire Berisha, Christoph K. Hitzenberger, Maciej Wojtkowski, Tomasz Bajraszewski, and Adolf F. Fercher "Real-time measurement of in-vitro and in-vivo blood flow with Fourier domain optical coherence tomography", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); https://doi.org/10.1117/12.531327

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