Antitumor activity of photodynamic therapy, adoptive immunotherapy, and chemotherapy in experimental tumor

Gianfranco L. Canti M.D.; Angela Calastretti; Rinaldo Cubeddu; Paola Taroni; Gianluca Valentini; Elena Reddi; Giuseppe Palumbo

doi:10.1117/12.529037

1 July 2004 Antitumor activity of photodynamic therapy, adoptive immunotherapy, and chemotherapy in experimental tumor

Gianfranco L. Canti M.D., Angela Calastretti, Rinaldo Cubeddu, Paola Taroni, Gianluca Valentini, Elena Reddi, Giuseppe Palumbo

Author Affiliations +

Proceedings Volume 5319, Laser Interaction with Tissue and Cells XV; (2004) https://doi.org/10.1117/12.529037
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Since Photodynamic therapy(PDT) is able to increase the antitumor immunity, in our laboratory we examine the antitumor effect of combination of PDT,with photoactivated Aluminium disulfonated Phthalocianine(ALS₂Pc),adoptive immunotherapy, with immune lymphocytes, and chemotherapy on aggressive murine tumor. Mice bearing L1210 tumor were treated at day +4 with PDT ( 5mg/Kg of AlS₂Pc and 100mW/cm² x 10’ of exposure of laser light 24hrs. later),at day +6 with Adriamycin(ADR 2mg/Kg) and at day + 7 with immune lymphocytes(IL),collected from L1210 bearing mice pretreated with PDT(2x10⁷ cells).The results show that the combination ADR + PDT + IL demonstrates a significant synergistic antitumor effect while the chemotherapy treatment with low dose of the drug and the adotive immunotherapy treatment are slightly effective. The same positive results were obtained with the combination of PDT,Cisplatin(CDDP 2mg/Kg) and IL,while the CDDP treatment alone and the Il treatment alone are slightly effective. In conclusion these results suggest that it is possible to completely cure animals bearing advanced tumors, with a combined therapy, PDT + adoptive immunotherapy + low dose chemotherapy.

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Gianfranco L. Canti M.D., Angela Calastretti, Rinaldo Cubeddu, Paola Taroni, Gianluca Valentini, Elena Reddi, and Giuseppe Palumbo "Antitumor activity of photodynamic therapy, adoptive immunotherapy, and chemotherapy in experimental tumor", Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); https://doi.org/10.1117/12.529037

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