Effect of micropulse duration on tissue ablation using a stretched free electron laser pulse train

John A. Kozub; Mark A. Mackanos; Marcus H. Mendenhall; E. Duco Jansen

doi:10.1117/12.535893

1 June 2004 Effect of micropulse duration on tissue ablation using a stretched free electron laser pulse train

John A. Kozub, Mark A. Mackanos, Marcus H. Mendenhall, E. Duco Jansen

Proceedings Volume 5340, Commercial and Biomedical Applications of Ultrafast Lasers IV; (2004) https://doi.org/10.1117/12.535893
Event: Lasers and Applications in Science and Engineering, 2004, San Jose, Ca, United States

Abstract

The pulse train from a Mark III FEL tuned to a wavelength of 6.45 microns has been shown to be efficient at ablating soft tissue with minimal collateral damage. This laser has a unique pulse structure consisting of a train of 1ps micropulses spaced 350ps apart, which is maintained for 4-5 microseconds (the macropulse) and is repeated at 1-30Hz. We are investigating the role of the pulse structure in the ablation mechanism. In order to determine the importance of non-linear effects potentially induced by the high peak power of the micropulses, we are using a grating pulse stretcher optimized for 6.45 microns to vary the micropulse duration while maintaining the macropulse duration and micropulse frequency. The technique allows use of the same pulse energy and average power with widely variable peak power. Ablation thresholds were measured using PROB-IT analysis and crater depths were measured using OCT imaging. In water, gelatin, and mouse dermis, we have found no statistically significant difference in the ablation threshold of pulses having widths of 1, 30, 60, and 100ps. The measured ablation efficiency of mouse dermis also showed no significant difference over the same range of pulse widths. This data suggests that the ablation characteristics obtained with the FEL at 6.45 microns are independent of the micropulse duration and do not rely on the high peak power of the FEL pulse train.

Citation Download Citation

John A. Kozub, Mark A. Mackanos, Marcus H. Mendenhall, and E. Duco Jansen "Effect of micropulse duration on tissue ablation using a stretched free electron laser pulse train", Proc. SPIE 5340, Commercial and Biomedical Applications of Ultrafast Lasers IV, (1 June 2004); https://doi.org/10.1117/12.535893

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