Measuring glucose concentration by Raman spectroscopy using liquid core optical fibers

Huaimin Gu; Da Xing; Huajiang Wei

doi:10.1117/12.572432

29 July 2004 Measuring glucose concentration by Raman spectroscopy using liquid core optical fibers

Huaimin Gu, Da Xing, Huajiang Wei

Proceedings Volume 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics; (2004) https://doi.org/10.1117/12.572432
Event: ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, 2003, Silsoe, United Kingdom

Abstract

We have studied Raman spectra of glucose aqueous solutions by using a long Teflon-AF2400 liquid core optical fiber (LCOFs), and have measured the glucose concentrations in solutions according to Raman spectra of solutions. We also have compared Raman Spectra of aqueous glucose solutions collected in LCOFs with those collected in a conventional 90° scattering geometry, and have obtained a detection sensitivity enhancement factor more than 100. A clear correlation between glucose Raman signals and glucose concentrations has been established by data analysis. It has shown that compared to conventional methods. LCOFs can provide higher Raman signal intensities, higher detection sensitivity and signal-to-noise rate in Raman spectroscopy measurements, in which the effective optical path length through the liquid sample is much longer than it would normally be. This study demonstrates the feasibility of measuring accurately glucose concentration by Raman spectroscopy using LCOFs, and can be used to evaluate the potential of Raman spectroscopy using LCOFs to perform microanalysis and measurements of liquid analytes in solutions with clinical accuracy. This technique is capable of measuring the concentration of other Raman-active liquid samples and complicated biology system.

Citation Download Citation

Huaimin Gu, Da Xing, and Huajiang Wei "Measuring glucose concentration by Raman spectroscopy using liquid core optical fibers", Proc. SPIE 5486, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, (29 July 2004); https://doi.org/10.1117/12.572432

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KEYWORDS

Raman spectroscopy

Glucose

Liquids

Raman scattering

Laser scattering

Signal detection

Scattering

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