Mesospaced surface for DNA microarray and other applications

Bong Jin Hong; Chang Ok Kim; Soon Jin Oh; Joon Won Park

doi:10.1117/12.569695

29 December 2004 Mesospaced surface for DNA micro-array and other applications

Bong Jin Hong, Chang Ok Kim, Soon Jin Oh, Joon Won Park

Proceedings Volume 5593, Nanosensing: Materials and Devices; (2004) https://doi.org/10.1117/12.569695
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

We have studied ways to control density as well as spacing among functional groups. In particular, we observed that use of aziridine for the surface hyperbranching polymerization yielded extremely high surface density of primary amine that is useful for the immobilization of molecules of biological relevance such as oligo DNA. Also, an employment of dendrons of appropriate molecular architecture provided mesospacing among the reactive functional groups. The spacings was expected to guarantee the freedom of the biological macromolecules so that their properties are close to that in solution in spite of the confinement in the two dimensional world. We demonstrated that this was the case for oligonucleotide microarrays.

Citation Download Citation

Bong Jin Hong, Chang Ok Kim, Soon Jin Oh, and Joon Won Park "Mesospaced surface for DNA micro-array and other applications", Proc. SPIE 5593, Nanosensing: Materials and Devices, (29 December 2004); https://doi.org/10.1117/12.569695

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