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25 April 2005 Development of a brain tumor model for investigating the effects of photodynamic and anti-angiogenic therapies
Nzola De Magalhaes, Chung-Ho Sun, Steen J. Madsen, Henry Hirschberg, Bruce J. Tromberg
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Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.596910
Event: SPIE BiOS, 2005, San Jose, CA, United States
Abstract
An in vivo shell-less chick chorioallantoic membrane (CAM) brain tumor model has been developed to investigate the effects of photodynamic therapy (PDT) and anti-antiogenic treatments. Multicellular human glioma spheroids were placed on the CAM at day 7 of embryonic development. Angiogenesis was observed four days post implantation. Significant damage to the CAM vasculature was observed immediately following 5-aminolevulinic acid (ALA) mediated PDT.
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Nzola De Magalhaes, Chung-Ho Sun, Steen J. Madsen, Henry Hirschberg, and Bruce J. Tromberg "Development of a brain tumor model for investigating the effects of photodynamic and anti-angiogenic therapies", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.596910
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KEYWORDS
Photodynamic therapy
Tumors
Brain
Therapeutics
Blood vessels
Content addressable memory
Diagnostics
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