Novel GMR-based biochip

Ting-Chang Lee; Hsin-Chun Huang; Chih-Ming Wang; Che-Lung Hsu; Tsung-Hsun Yang; Jeng-Yang Chang

doi:10.1117/12.591455

7 March 2005 Novel GMR-based biochip

Ting-Chang Lee, Hsin-Chun Huang, Chih-Ming Wang, Che-Lung Hsu, Tsung-Hsun Yang, Jeng-Yang Chang

Proceedings Volume 5702, Optical Diagnostics and Sensing V; (2005) https://doi.org/10.1117/12.591455
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

For the detection of molecular interaction, a novel approach of the guided-mode resonance (GMR) spectroscopy identifies molecules via specific bindings with their ligands immobilized on the grating surface is presented. The structure of GMR device generally consists of two stages -- upper grating layer and waveguide layer. When the wide-band light illuminating, the GMR device inhibits on a specific resonant narrow-band of wavelength, and allows for other wavelength to transmit. The specific resonant narrow-band of wavelength results in the diffraction of the incident wide-band wave and the selection in the waveguide layer. This is very useful in highly sensitive measurement, especially for the variations in the refractive index of bulk media, and for the monitoring of variations in the thickness of thin film. In the simulation, one Si₃N₄ (n=2) GMR device is designed. When the wavelength of the illumination ranges from 1520nm to 1620nm, the resonant peak wavelength will shift 0.03nm as per 1nm bio-layer (n_bio 1.3) has been attached on. Finally, on the basis of the theoretical analysis, the optimization of a spectral GMR sensor in terms of the operation wavelength has been carried out.

Citation Download Citation

Ting-Chang Lee, Hsin-Chun Huang, Chih-Ming Wang, Che-Lung Hsu, Tsung-Hsun Yang, and Jeng-Yang Chang "Novel GMR-based biochip", Proc. SPIE 5702, Optical Diagnostics and Sensing V, (7 March 2005); https://doi.org/10.1117/12.591455

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available