Development of a PCR free, fieldable, rapid, accurate, and sensitive bio-electronic DNA biosensor

Doyle Hill; David Chafin; Roberta Greco; Samina Jafri; Richard Murante; John Noonan; An Pham; Scott Seabridge; Vera Tannous; Karl VanDerMeid; Daguang Wang; Nate Wescott; Kristin McFarlane; Sanjiv Shah

doi:10.1117/12.606722

20 May 2005 Development of a PCR free, fieldable, rapid, accurate, and sensitive bio-electronic DNA biosensor

Doyle Hill, David Chafin, Roberta Greco, Samina Jafri, Richard Murante, John Noonan, An Pham, Scott Seabridge, Vera Tannous, Karl VanDerMeid, Daguang Wang, Nate Wescott, Kristin McFarlane, Sanjiv Shah

Author Affiliations +

Proceedings Volume 5778, Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Security and Homeland Defense IV; (2005) https://doi.org/10.1117/12.606722
Event: Defense and Security, 2005, Orlando, Florida, United States

Abstract

The objective of this study was to demonstrate proof of concept for the Integrated Nano-Technologies BioDetect Bacillus anthracis electronic DNA sensor. B. anthracis Ames strain DNA was successfully detected by the formation of DNA bridges on the sensor. The bridges were coated with metal, resulting in a significant drop in electrical resistance. In this small test, at a relatively high DNA concentration, the overall accuracy of the sensor was 90.7%. The technology shows significant promise for future development as a bio-agent detection system.

Citation Download Citation

Doyle Hill, David Chafin, Roberta Greco, Samina Jafri, Richard Murante, John Noonan, An Pham, Scott Seabridge, Vera Tannous, Karl VanDerMeid, Daguang Wang, Nate Wescott, Kristin McFarlane, and Sanjiv Shah "Development of a PCR free, fieldable, rapid, accurate, and sensitive bio-electronic DNA biosensor", Proc. SPIE 5778, Sensors, and Command, Control, Communications, and Intelligence (C3I) Technologies for Homeland Security and Homeland Defense IV, (20 May 2005); https://doi.org/10.1117/12.606722

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available