Independent component analysis for three-dimensional optical imaging and localization of a fluorescent contrast agent target embedded in a slab of ex vivo human breast tissue

M. Alrubaiee; M. Xu; S. K. Gayen; R. R. Alfano

doi:10.1117/12.632875

7 October 2005 Independent component analysis for three-dimensional optical imaging and localization of a fluorescent contrast agent target embedded in a slab of ex vivo human breast tissue

M. Alrubaiee, M. Xu, S. K. Gayen, R. R. Alfano

Author Affiliations +

Proceedings Volume 5859, Photon Migration and Diffuse-Light Imaging II; 585919 (2005) https://doi.org/10.1117/12.632875
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

An innovative approach for three-dimensional localization and characterization of a fluorescent target embedded in a turbid medium is presented. The target was a ~4-mm diameter glass sphere with a solution of indocyanine green placed within a 50-mm thick tissuelike phantom with mean free path of ~1-mm at 784-nm and a ~ 26-mm thick ex vivo breast tissue slab. The experimental approach uses a multi-source illumination, and a multi-detector signal acquisition scheme. An analysis scheme based on the independent component analysis from information theory is used for target localization and characterization. Independent component analysis of the perturbation in the spatial intensity distribution of the fluorescent signal measured on the exit plane of the turbid medium locates the embedded objects. The location and size, of the embedded objects are obtained from a Green's function analysis and back-projection Fourier transform of the retrieved independent components.

Citation Download Citation

M. Alrubaiee, M. Xu, S. K. Gayen, and R. R. Alfano "Independent component analysis for three-dimensional optical imaging and localization of a fluorescent contrast agent target embedded in a slab of ex vivo human breast tissue", Proc. SPIE 5859, Photon Migration and Diffuse-Light Imaging II, 585919 (7 October 2005); https://doi.org/10.1117/12.632875

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Independent component analysis

3D acquisition

Breast

3D image processing

Optical imaging

Tissue optics

Tissues

Show All Keywords

Keywords/Phrases

Search In:

Publication Years