CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 6386 > Article
Paper
17 October 2006 Optical speckle angular correlation and fractal property of a composite of cancer/normal cell layers with application for laboratory monitoring of drug efficacy
Regina Sullivan, R. Subramaniam, P. S. Schneider, A. Flamholz, G. Tremberger Jr., E. Cheung, S. Rotenberg, P. K. Wong, D. H. Lieberman, T. D. Cheung, Rafael Perez
Author Affiliations +
Proceedings Volume 6386, Optical Methods in the Life Sciences; 63860B (2006) https://doi.org/10.1117/12.686241
Event: Optics East 2006, 2006, Boston, Massachusetts, United States
Abstract
Breast cancer cells and normal cells were grown on glass substrates and investigated via laser generated speckles. The optical speckle pattern of a layer was investigated via angular correlation and fractal dimension analysis. A porous silicate slab with various water contents was used as calibration. The angular correlation and its associated Fourier transform results were consistent with the property of the cells. The speckle intensity data can be treated as a random series and the Higuchi method was used to explore the fractal property of the random series. The fractal dimension results differentiated the cancer cells (fractal dimension about 1.5) from the normal cells (fractal dimension about 1.8). The Fourier transformed series showed fractal dimension results consistent with cell functions. A composite of breast cancer/normal cell matrix was built with cancer cell layers embedded within normal cell layers. The optical speckle pattern of a composite was investigated and computer modeling was used to extract the embedded cancer cell fractal dimension information. The measurement of the efficacy of a drug was simulated with the monitoring of the effect of added chemicals in the growth media. Laboratory optical speckle pattern monitoring of the effect of added chemicals was discussed. The extension for early cancer detection in mammography was also discussed and an example of the application of the anisotropic spatial variation of the fractal dimension via the Higuchi fractal method was presented.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Regina Sullivan, R. Subramaniam, P. S. Schneider, A. Flamholz, G. Tremberger Jr., E. Cheung, S. Rotenberg, P. K. Wong, D. H. Lieberman, T. D. Cheung, and Rafael Perez "Optical speckle angular correlation and fractal property of a composite of cancer/normal cell layers with application for laboratory monitoring of drug efficacy", Proc. SPIE 6386, Optical Methods in the Life Sciences, 63860B (17 October 2006); https://doi.org/10.1117/12.686241
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 11 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Fractal analysis
Speckle
Breast
Mammography
Cancer
Microscopes
Composites
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top