Influence of refractive index and molecular weight of alcohol agents on skin optical clearing effect

Zhongzhen Mao; Ying Zheng; Yating Hu; Wei Lu; Qingming Luo; Dan Zhu

doi:10.1117/12.701701

7 February 2007 Influence of refractive index and molecular weight of alcohol agents on skin optical clearing effect

Zhongzhen Mao, Ying Zheng, Yating Hu, Wei Lu, Qingming Luo, Dan Zhu

Proceedings Volume 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV; 64360O (2007) https://doi.org/10.1117/12.701701
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

In order to discuss the relative factors affecting the optical clearing effect of agents on skin tissues, six hydroxy-terminated and saturated alcohols with different refractive index and molecular weight were chosen as the optical clearing agents (OCAs). After being treated by different OCAs, the change of transmitted intensity of porcine skins in vitro was measured by single integrating sphere system. The results showed the optical clearing effects of six OCAs, i.e., glycerol, PEG400, PEG200, 1,3-propylene glycol, 1,4-butanediol and 1-butanol, arranged in the descending order. Based on the above results, the refractive index and molecular weight was further discussed. The optical clearing effect of alcohols has been deduced to have negative correlation with refractive index (r=-0.608), but no correlation with molecular weight (r= 0.008).

Citation Download Citation

Zhongzhen Mao, Ying Zheng, Yating Hu, Wei Lu, Qingming Luo, and Dan Zhu "Influence of refractive index and molecular weight of alcohol agents on skin optical clearing effect", Proc. SPIE 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV, 64360O (7 February 2007); https://doi.org/10.1117/12.701701

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