Imaging Hemodynamic Effects of ET-1 on Cerebral Blood Flow in Rats

Adrien Ponticorvo; W. J. Tom; M. Aura; T. A. Jones; A. K. Dunn

doi:10.1117/12.700967

16 February 2007 Imaging hemodynamic effects of ET-1 on cerebral blood flow in rats

Adrien Ponticorvo, W. J. Tom, M. Aura, T. A. Jones, A. K. Dunn

Proceedings Volume 6446, Biomedical Applications of Light Scattering; 64460U (2007) https://doi.org/10.1117/12.700967
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Endothelin-1 (ET-1) is a potent vasoconstrictor sometimes used in studies of cerebral ischemia. Its ability to create ischemic regions of various sizes with little additional damage has made it a popular tool in evaluating anti-stroke drugs. Despite its emergence in stroke models, it remains poorly characterized. Attempts to do this with Laser Doppler Flowmetry (LDF) or a histological analysis provide good temporal resolution or good spatial resolution respectively, but not both. An imaging modality that provides both temporal and spatial resolution would be able to better characterize the acute and chronic effects of ET-1 on cerebral blood flow. We have used laser speckle contrast imaging to study the effects of ET-1 after topical application on rats. We observed an immediate decrease in blood flow corresponding to the amount of ET-1 used. After the initial decrease, the blood flow slowly increases towards the baseline value with occasional vasospastic responses observed. Future studies involving multi-spectral reflectance imaging combined with the laser speckle contrast analysis would lead to a better understanding of the hemodynamic effects of ET-1.

Citation Download Citation

Adrien Ponticorvo, W. J. Tom, M. Aura, T. A. Jones, and A. K. Dunn "Imaging hemodynamic effects of ET-1 on cerebral blood flow in rats", Proc. SPIE 6446, Biomedical Applications of Light Scattering, 64460U (16 February 2007); https://doi.org/10.1117/12.700967

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